目录
DNA序列简述其代码原始序列上进行替换利用upper()输出大写结果结尾DNA序列
ACTGATCGATTACGTATAGTATTTGCTATCATACATATATATCGATGCGTTCAT
求其互补DNA序列。
在生物上DNA互补序列简述表达可以表示为:A与T,C与G互补,可以理解为将上述序列中现有的A用T代替,C用G代替,T用A代替,G用C代替,则其互补序列为:
【资料图】
TGACTAGCTAATGCATATCATAAACGATAGTATGTATATATAGCTACGCAAGTA
根据上述表述,我可以利用replace()函数进行替换,将A用T替换,T用A替换,C用G替换,G用C替换,
简述其代码
my_dna = "ACTGATCGATTACGTATAGTATTTGCTATCATACATATATATCGATGCGTTCAT" # replace A with T sequence1 = my_dna.replace("A", "T") # replace T with A sequence2 = sequence1.replace("T", "A") # replace C with G sequence3 = sequence2.replace("C", "G") # replace G with C sequence4 = sequence3.replace("G", "C") # print the result of the final replacement print(sequence1) print(sequence2) print(sequence3) print(sequence4)
其输出结果如下:
TCTGTTCGTTTTCGTTTTGTTTTTGCTTTCTTTCTTTTTTTTCGTTGCGTTCTT
ACAGAACGAAAACGAAAAGAAAAAGCAAACAAACAAAAAAAACGAAGCGAACAA
AGAGAAGGAAAAGGAAAAGAAAAAGGAAAGAAAGAAAAAAAAGGAAGGGAAGAA
ACACAACCAAAACCAAAACAAAAACCAAACAAACAAAAAAAACCAACCCAACAA
原始序列上进行替换
显然结果是不正确的,我们在sequence1到sequence2中就已经出现错误,误把sequence1中A被替换之后变为T的序列,在sequence2中又被替换掉了,因此我们要转变思路,保持只替换原本的序列,不进行多次替换,避免错误,我们可以尝试每次只在原始序列上进行替换,尝试代码如下:
my_dna = "ACTGATCGATTACGTATAGTATTTGCTATCATACATATATATCGATGCGTTCAT" # replace A with T sequence = my_dna.replace("A", "T") # replace T with A sequence2 = my_dna.replace("T", "A") # replace C with G sequence3 = my_dna.replace("C", "G") # replace G with C sequence4 = my_dna.replace("G", "C") print(sequence1) print(sequence2) print(sequence3) print(sequence4)
其输出结果如下:
TCTGTTCGTTTTCGTTTTGTTTTTGCTTTCTTTCTTTTTTTTCGTTGCGTTCTT
ACAGAACGAAAACGAAAAGAAAAAGCAAACAAACAAAAAAAACGAAGCGAACAA
AGTGATGGATTAGGTATAGTATTTGGTATGATAGATATATATGGATGGGTTGAT
ACTCATCCATTACCTATACTATTTCCTATCATACATATATATCCATCCCTTCAT
显然结果也是不正确的,因此,我们要引入中间变量,最后再把它做一个回环,
也就是说引入四个临时字母,然后每个变换2次,最后把最终结果输出,其代码可以为:
my_dna = "ACTGATCGATTACGTATAGTATTTGCTATCATACATATATATCGATGCGTTCAT" sequence1 = my_dna.replace("A", "H") sequence2 = sequence1.replace("T", "J") sequence3 = sequence2.replace("C", "K") sequence4 = sequence3.replace("G", "L") sequence5 = sequence4.replace("H", "T") sequence6 = sequence5.replace("J", "A") sequence7 = sequence6.replace("K", "G") sequence8 = sequence7.replace("L", "C") print(sequence8)
其结果为:
TGACTAGCTAATGCATATCATAAACGATAGTATGTATATATAGCTACGCAAGTA
利用upper()输出大写结果
至此得到了我们想要的结果,但这种方法显然是有些复杂了,我们可以利用字符的大小写来完成我们的工作,也就是利用小写字母为临时变量,最终利用upper()输出大写的结果就行了,其代码和结果如下:
my_dna = "ACTGATCGATTACGTATAGTATTTGCTATCATACATATATATCGATGCGTTCAT" sequence1 = my_dna.replace("A", "t") print(sequence1) sequence2 = sequence1.replace("T", "a") print(sequence2) sequence3 = sequence2.replace("C", "g") print(sequence3) sequence4 = sequence3.replace("G", "c") print(sequence4) print(sequence4.upper())
其结果为:
tCTGtTCGtTTtCGTtTtGTtTTTGCTtTCtTtCtTtTtTtTCGtTGCGTTCtT
tCaGtaCGtaatCGatatGataaaGCataCtatCtatatataCGtaGCGaaCta
tgaGtagGtaatgGatatGataaaGgatagtatgtatatatagGtaGgGaagta
tgactagctaatgcatatcataaacgatagtatgtatatatagctacgcaagta
TGACTAGCTAATGCATATCATAAACGATAGTATGTATATATAGCTACGCAAGTA
至此我们的互补DNA序列得到了,也许有更好更简洁的代码。
结尾
虽然这是个小小的计算程序,但对于初学者的我来说每一次对原代码的升级改造,哪怕是读懂后的注释都感觉是一次进步提升,总之代码虽小,动手最重要!希望更多学习Python的爱好者不要像我一样眼高手低,学习编程就是要,思考,敲码,思考,敲码,敲码,再敲码,更多关于python求DNA模板互补序列的资料请关注脚本之家其它相关文章!
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